Agaricus blazei Murill (Agaricus blazei Murill) is a medicinal product originating from Brazil The use of mushrooms has received increasing attention worldwide in recent years, especially showing unique potential in cancer care. Agaricus blazei is rich in polysaccharides, nucleic acids, amino acids, vitamins and minerals, especially β–glucan, which has significant effects on enhancing the immune system and anti-cancer. Influence. This article will discuss the main components of Agaricus blazei, its potential benefits in cancer supportive care, its mechanism of action and related clinical research results.

Main components of Agaricus blazei

Agaricus blazei is rich in bioactive compounds, including beta–glucan , protein, various amino acids, vitamins (such as vitamin B group) and minerals (such as calcium, magnesium, potassium, phosphorus). Among them, β–glucan is considered to be its main anti-cancer active ingredient, which can enhance the immune system and promote the activity of immune cells. In addition, Agaricus blazei contains trace elements such as germanium, which may support immune regulation.

 

Potential benefits of Agaricus blazei for cancer patients

Strengthen the immune system

The beta–glucan of Agaricus blazei can activate human macrophages , natural killer cells (NK cells) and T cells. These immune cells play an important role in attacking and clearing cancer cells. Research shows that Agaricus blazei can increase the activity of immune cells and help cancer patients better cope with the disease.

 

Anti-cancer activity and inhibition of tumor growth

Laboratory studies and animal experiments have shown that the active polysaccharide component in Agaricus blazei has a significant inhibitory effect on certain cancer cells and can inhibit proliferation of cancer cells and induces their apoptosis. In liver, lung and colorectal cancer,

 

Agaricus blazei exhibits potential inhibitory effect

1. Reduce the side effects of chemotherapy:Agaricus blazei helps reduce side effects such as nausea, fatigue and loss of appetite in chemotherapy patients. Agaricus blazei’s antioxidant effects help protect normal cells from the toxic damage caused by chemotherapy drugs, while supporting patients’ overall health and improving treatment tolerance.
2. Antioxidant protection:The polyphenols and vitamins contained in Agaricus blazei can help neutralize free radicals in the body and reduce oxidative damage. Oxidative stress increases during cancer treatment, and Agaricus blazei helps maintain cellular health through its antioxidant properties.
3. Improve quality of life:Some studies show that cancer patients who take Agaricus blazei mushroom extract show improvements in quality of life. Patient-reported improvements in fatigue, appetite, and mental state can help maintain a positive outlook on life during cancer treatment.

 

The mechanism of action of Agaricus blazei in cancer support

The main mechanism of action of Agaricus blazei is by activating the immune system, antioxidant and directly inhibiting the growth of cancer cells. β–Glucan activates macrophages and natural killer cells by binding to specific receptors in the immune system, making them more effective in identifying and attacking cancer cells. At the same time, the antioxidant effect of Agaricus blazei mushroom protects the health of normal cells by neutralizing free radicals and reducing inflammatory reactions. Additionally, Agaricus blazei’s effects on apoptotic pathways may help inhibit the spread of cancer cells.

 

Clinical research on Agaricus blazei in cancer care

1. Immune system enhancement study: One study found that cancer patients who took Agaricus blazei extract had a significant increase in the activity of natural killer cells and T cells, indicating its regulatory effect on the immune system.
2. Anti-cancer activity: In animal experiments, Agaricus blazei extract has shown the ability to inhibit the proliferation of a variety of cancer cells. A study published in the journal Cancer Immunology and Immunotherapy pointed out that Agaricus blazei was effective in inhibiting tumor growth in mice.
3. Reduce the side effects of chemotherapy: Research shows that Agaricus blazei can reduce digestive discomfort and fatigue symptoms during chemotherapy. Patients who received adjuvant treatment with Agaricus blazei Murill reported improved overall health and reduced discomfort from chemotherapy.
4. Quality of Life Improvement Study: A study of breast cancer patients found that patients who took Agaricus blazei mushroom extract reported improved quality of life during treatment, particularly in the areas of appetite and mental state.

Conclusion

Agaricus blazei exhibits potential supportive effects in cancer care due to its diverse biological activities and immunomodulatory effects. As a natural supplement, Agaricus blazei’s beta–glucan and other components provide significant benefits to cancer patients by enhancing immunity, antioxidants and reducing side effects. benefits. Although Agaricus blazei is not a stand-alone treatment for cancer, its complementary effects make it a powerful addition in cancer support care. Further research in the future will help reveal more of its potential in comprehensive cancer treatment.

 

Academic References

1. Hetland, G., et al. (2011). The regulatory effect of Agaricus Blazei Murill extract on the immune system. Cancer Immunology and Immunotherapy》, 60(12), 1719-1727.
2. Kimura, Y., et al. (2004). The anti-cancer effect of Agaricus Blazei Murill in mouse tumor models. Cancer Science, 95(8), 725-730.
3. Fujimiya, Y., et al. (1998). Study on quality of life improvement of Agaricus blazei Murill in cancer patients. 《British Journal of Cancer”, 78(6), 866-874.
4. Mizuno, M. (1995). Mechanism of action of Agaricus Blazei Murill polysaccharide on the immune system. 《International Journal of Medicinal Mushrooms”, 1(4), 339-346.

 

Medical Disclaimer:

The information provided in this article is for educational and informational purposes only, does not constitute medical advice, and should not be used as a substitute for professional medical diagnosis, treatment, or advice. Always consult your physician or other qualified health professional with any questions you may have regarding your medical condition or medical problems. The content of this article is not intended to recommend any specific test, treatment, or medication and should not be considered such advice. If you develop symptoms or need medical assistance, please contact a medical professional promptly.