Albumin
What is albumin?
Albumin is a protein made by your liver. Albumin enters your bloodstream and helps keep fluid from leaking out of your blood vessels into other tissues. It also helps carrying hormones, vitamins, and enzymes throughout your body
– Albumin is an important element in enzyme and kinetin synthesis
– Albumin also plays an important role in the delivery of nutrients in the body
– Albumin also plays a role in the body’s ability to stop bleeding
Why does cancer cause low level albumin level?
Under normal circumstances, our liver is constantly producing albumin. But when the cancer has advanced or spread throughout the body, albumin levels may drop to a relatively low level. Cancer patients who had receiving different treatments such as surgery, radiotherapy, and chemotherapy, which will affect their liver function to a certain extent, this result in low albumin levels.
The main cause of low albumin level:
The main functions of Enhanced Wellness Booster (5 in 1) Enhanced Wellness Booster come from GLUTATHIONE, ALPHA-LIPOIC ACID, vitamin C, folic acid and vitamin B12. The details of its efficacy are as follows:
- Insufficient nutrition caused by:
- Difficulty in food consumption: resulting in nutrient deficiencies
- Unbalanced diet
- Synthetic disorder: the “hepatic ability to synthesis albumin ” is reduced due to various liver diseases.
- Excessive loss: excessive consumption caused by ascites, surgery, and advanced tumors
How does low level in albumin affect the body?
- When liver function is impaired, the production of albumin will decrease accordingly, and the degree of decrease is parallel to the severity of hepatitis. The concentration of serum albumin in patients with chronic and severe hepatitis and liver cirrhosis are relatively lower. Low albumin level in liver function tests often indicates that the liver has been damaged. The lower the albumin value, the more serious the liver damage.
- Another function of albumin is to nourish cells and maintain intravascular osmotic pressure. When the albumin level decline, the intravascular osmotic pressure decreases subsequently, patients may experience ascites.
- Albumin is an important nutrient in the human body, which can maintain nutritional balance in the human body. When albumin level is low, malnutrition may appear.
- If the content of albumin in the serum decreases, the colloid osmotic pressure in the plasma will decrease, which will lead to excessive fluid in the blood. The excessive fluid will enter and mix with tissue fluid which cause edema. In severe cases, ascites and body edema may occur.
How to deal with low albumin level?
1. Adjust your diet and eat more foods rich in protein and vitamins
2. Intravenous infusion of albumin etc., (Under doctor guidance is needed)
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References
Research on the Physiological Functions and Clinical Applications of Albumin:
- Peters T Jr. All About Albumin: Biochemistry, Genetics, and Medical Applications. Academic Press. 1996.
- Fanali G, Di Masi A, Trezza V, et al. Human serum albumin: From bench to bedside. Mol Aspects Med. 2012;33(3):209–290. doi:10.1016/j.mam.2012.03.001.
- Levitt DG, Levitt MD. Human serum albumin homeostasis: A new look at the roles of synthesis, catabolism, renal and gastrointestinal excretion. Clin Biochem. 2016;49(1-2):12–22. doi:10.1016/j.clinbiochem.2015.11.015.
Research on Hypoalbuminemia and Health Status in Cancer Patients:
- McMillan DC, Watson WS, O’Gorman P, et al. Albumin concentrations are primarily determined by the systemic inflammatory response in cancer patients with weight loss. Nutr Cancer. 2001;39(2):222–227. doi:10.1207/S15327914NC392_8.
- Caccialanza R, Pedrazzoli P, Cereda E, et al. Nutritional support in cancer patients: A position paper from the Italian Society of Medical Oncology. Clin Nutr. 2019;38(5):1951–1968.
- Arends J, Bachmann P, Baracos V, et al. ESPEN guidelines on nutrition in cancer patients. Clin Nutr. 2017;36(1):11–48. doi:10.1016/j.clnu.2016.07.015.
Research on Albumin Levels and Cancer Prognosis:
- Gupta D, Lis CG. Pretreatment serum albumin as a predictor of cancer survival: a systematic review of the epidemiological literature. Nutr J. 2010;9:69. doi:10.1186/1475-2891-9-69.
- Lis CG, Grutsch JF, Vashi PG, Lammersfeld CA. Is serum albumin an independent predictor of survival in patients with cancer? A systematic review. Nutr J. 2008;7:17.
- Gupta D, Lis CG. Role of inflammation in the development of cancer cachexia and its association with survival. Clin Nutr. 2014.
Research on Intravenous Albumin Therapy and Clinical Applications:
- Finfer S, Bellomo R, Boyce N, et al. A comparison of albumin and saline for fluid resuscitation in the intensive care unit. N Engl J Med. 2004;350:2247–2256. doi:10.1056/NEJMoa040232.
- Schierhout G, Roberts I. Fluid resuscitation with colloid or crystalloid solutions in critically ill patients: a systematic review of randomised trials. BMJ. 1998;316:961–964.
- Caironi P, Tognoni G, Masson S, et al. Albumin replacement in patients with severe sepsis or septic shock. N Engl J Med. 2014;370:1412–1421.